Moreover, odors, especially perfumes and cleaning products, can trigger headaches in around 45% of these patients, and this seems to be specific to migraine headaches. Osmophobia (aversion and intolerance to odors) in particular, affects up to 90% of the migraine patients and is also experienced interictally, i.e. Accumulating data emphasizes the importance of olfaction in migraine pathophysiology. Migraine attacks are more common in women than in men, last longer and are more disabling. The cerebral overlap between trigeminal nociception and olfaction might explain these deficits.Īmong neurological disorders, migraine is the leading cause of disability and is associated with increased sensitivity to light, sound, touch, and smell. Patients with aura have a bigger deficit in engaging secondary olfactory-related structures, possibly leading to distorted attention and judgements towards odors. ConclusionsĪltogether this may reflect hypersensitivity to nociceptive stimuli in patients with aura relative to patients without aura. Oscillations in the low frequency bands (< 8 Hz) differed between patient groups. Following olfactory stimulations patients with aura displayed decreased neural activity in secondary olfactory structures compared to patients without aura.
Patients with aura had higher event-related potentials amplitudes for left-sided trigeminal and left-sided olfactory stimulations, and higher neural activity for right-sided trigeminal stimulation in brain areas related to trigeminal and visual processing. Source reconstruction analysis was also performed. Data were analyzed in the time domain and in the time–frequency domain. Patients were tested in interictal state only. This cross-sectional study recorded event-related potentials from 64 electrodes during a pure olfactory or pure trigeminal stimulus in females with episodic migraine with aura ( n = 13) and without aura ( n = 15), to characterize the central nervous processing of these intranasal stimuli. However, there are only a few studies evaluating how the migraine brain processes olfactory stimulation, and virtually no studies comparing patients with and without aura in this context.
0 kommentar(er)
